HW 4 Aromatic Substitution_page_1
CHEM 3332 Honors Homework for Aromatic Substitution 1. Predict the major product (or products) for these reactions. Don’t forget to show…
HW 4 Aromatic Substitution_page_2
(e) OH {e) Cl H N cl Diclofenac Bro, FeBr3 —————> Bro, FeBr3 ——————> 1) HNO, H,SO, 2) Bro, FeBr3 AICI, cl CO,H +NO,
HW 4 Aromatic Substitution_page_3
NO, Ss Bro, FeBr3 OO OMe OMe » HAY fe) , acid 2) heat 1) HNO3, H,SO, 2) Hp, Pd/C ——___» Cr 3) NaNO,, HCI 4) CuCN, KCN 5) Ha, Pd/C I PdCl,,…
HW 4 Aromatic Substitution_page_4
0 Br», FeBrs 1) Mg°, then B(OMe) 3 2) KOH _ AB +B Pd(PPh3)q,
HW 4 Aromatic Substitution_page_5
E. MeO MeO ZA OH OH 3. Write a full mechanism for the following: A. | Bro, di | N rp, dioxane N B —___»> r Ww wa B. Cl OMe NO, NaOCH;,…
HW 4 Aromatic Substitution_page_6
1) CH3COCI, AICI; NO, ——_ 2) HNO3, H,SO, 3) Hp, Pd/C, EtOH Et D. 1) NaNO,, H,SO, ———— vH 2) CuCN, KCN N CN Me OMe a. NaOCHo, CHSOH CH,0H ON…